摘要
大鼠颈外静脉注射内毒素和血小板激活因子(PAF)均可诱发严重肺水肿,肺血管外水量,肺泡灌洗液中蛋白浓度、细胞计数和多形核粒细胞分类均显著增高。PAF受体拮抗剂SRI63—441对内毒素和PAF所致肺水肿和肺泡灌洗液细胞学变化有部分改善作用。
A bolus injection of endotoxin and platelet activating factor ( PAF ) via external jugular vein in rats resulted in severe pulmonary edema, accompanied by significant increase in extravascular lung water volume, bronchoalveolar lavage fluid ( BALF ) protein concentration, BALF cell counts and polymorphonuclearcyte percentage. PAF receptor antagonist SRI63-441 showed partial protective effects on endotoxin and PAF induced lung edema and BALF cytological changes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第3期168-170,共3页
Chinese Pharmacological Bulletin
关键词
受体拮抗剂
内毒素
血小板
肺损伤
Endotoxin
Platelet-activating factor
Receptor antagonist
Lung injury
Bronchoalveolar lavage
