摘要
钙拮抗剂维拉帕米(VER)和硝苯吡啶(NIF)可明显抑制离体大鼠输卵管标本的自发性收缩活动,用求积仪测得的5min收缩曲线面积表明:VER、NIF给药后面积均明显小于给药前,呈剂量依赖性,在整体实验中VER、NIF可使妊娠3d大鼠输卵管内卵的运行加速,与对照组比较,用药组在子宫腔内回收到的卵数明显多于对照组,合笼实验证明VER、NIF没有抗着床作用。
Calcium blockers verapamil ( VER ) and nifedipine ( NIF ) appa-rentely inhibited the spontaneous activity of isolated rat oviduct. The 5 min contractile curve aera determined by integrator,after eithet VER or NIF effected, was smaller than that before,with dose dependence.In rats pregnanant for 3d VER and NIF accelerated ovum transport through oviduct. The number of ovum recovered from uterus in test group was more than that in control group. Paired experiments showed VER and NIF having no anti-implantation action.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1990年第3期165-168,共4页
Chinese Pharmacological Bulletin
关键词
维拉帕米
硝苯吡啶
输卵管
卵转运
Calcium blockers
Verapamil
Nifedipne
Oviduct
Ovum transport
Anti-implantation
