三七根总皂甙的抗炎作用及其作用机制

ANTI-INFLAMMATORY EFFECT OF TOTAL SAPONINS OF ROOT OF PANAX NOTOGINSENG ( TSPR )

TSPR与HC相似,一次或连续im都能明显对抗巴豆油诱发小鼠和大鼠耳壳的炎症。对小鼠ip冰醋酸诱发的渗出性炎症,对大鼠、小鼠由埋藏棉球诱发肉芽组织增生的慢性炎症,亦有明显的抑制作用。其抗炎作用与垂体—肾上腺系统无明显关系。当切除双侧肾上腺后,TSPR仍有明显的抗炎作用。试管内实验发现TSPR能明显抑制血清蛋白的加热变性,并对红细胞膜有稳定作用。

The anti-inflammatory effect of total saponins of Panax notoginseng (TSPR ) were reported. After intramuscular injection of TSPR (200 mg/kg, rats and mice) and hydrocortisone ( 300mg/kg, rats ; 200mg/ kg, mice) the ear inflammation induced by croton oil decreased. Thirty minutes after intramuscular injection of TSPR ( 200mg/kg ) and hydrocortisone ( 200mg/kg ) in normal mice, the inflammation induced by acetici ( ip) shown by the infiltration of Even's blue decreased significantly.It is suggested antiinflammatory effect of TSPR was not related to the hypothalamic adrenal system. In chronic inflammatory experiments, TSPR as well as hydrocortisone could inhibit the proliferation of granuloma by the implantation of cotton pellet in rats and mice with inhibitory rates of 27.6% ( P< 0.01 ) , 34.4% ( P<0.01 ) and 43.25% ( P<0.01 ) , 47.25% ( P<0.01 ) respectively. The protein denaturation and erythrocytes hemolysis with heat in vitro could be inhibited by TSPR and Analginum.