肺部肿瘤手术前后免疫功能检测临床意义

目的:探讨肺部良、恶性肿瘤手术前后免疫功能检测临床意义。方法:良、恶性肺部肿瘤患者分为两组,手术前及术后第1、8、15天应用免疫荧光法检测淋巴细胞亚群,包括总T淋巴细胞(CD3+)、T辅助细胞(CD4+)、T抑制细胞(CD8+)、CD4+/CD8+、自然杀伤细胞NK,并对其进行统计学处理。结果:两组患者术后第1天的NK活性、和CD3+、CD4+细胞及CD4+/CD8+比值明显低于术前,CD8+细胞则明显高于术前,相差均非常显著性差异(P<0.01);术后第8天良、恶性肺部肿瘤组的NK活性及T淋巴细胞亚群的指标逐渐升高,术后第15天除CD8+细胞及CD4+/CD8+与术前相差显著外(P<0.05),其他指标均接近术前水平,无明显差异,结论:良、恶性肺部肿瘤患者的免疫功能于术后不同时间有不同程度的恢复,可为临床治疗提供参考。肺癌术后对患者的肿瘤免疫功能有很大的负面作用,其时间可达2周以上。为微转移的发生、发展提供了适宜的环境,对近远期愈后影响明显。

objective：lung good,malignant tumor surgery and immune function testing clinical significance.Methods：good,malignant lung tumor patients weredivided into two groups,before the operation and the number of applications 1,8,15 days immunofluorescence test achroacyte subgroup,including total T lymphocyte（CD3^＋）,T helper cells （CD4^＋）,T inhibiting cell（CD8^＋）,CD4^＋/CD8^＋,natural killer cells NK and carries on the statistics processing.Results：two groups of patients who underwent the first days of NK activity and CD3^＋,CD4^＋ cells and CD4^＋/CD8^＋ ratio obviously lower than preoperative,CD8^＋ cells is obviously higher than preoperative,differ are very significant（P.01）;0 Postoperative 8 unbelieving,malignant lung tumor group NK activity and T achroacyte subgroup of index is increasing gradually,postoperative day 15 except CD8^＋cells and CD4^＋/CD8^＋ with preoperative differ significantly outside（P〈0.05）,other indexes close preoperative levels,no obvious difference.Cnclusion：good,malignant lung tumor patients＇ immune functions in postoperative different time had different degrees of recovery,can provide reference for clinical treatment.Lung cancer of the patient＇s cancer postoperative immune function is a negative effect,its time to 2 weeks more.To micro metastases,development provides a suitable environment for JinYuan Qi anthropogenic influence obviously.