SOCS超甲基化与肿瘤发生

Methylation of SOCS and Tumorigenesis

细胞因子信号转导抑制分子(suppressor of cytokine signaling,SOCS)是一类在细胞信号转导过程中发挥重要作用的负调控因子,可抑制多种细胞因子的信号转导,从而实现对体内多种免疫反应的调控作用.近年来研究发现,SOCS启动子区域内CpG岛的超甲基化导致的基因转录沉默与多种肿瘤的发生密切相关.SOCS蛋白作为信号转导途径的负调节物,代表着一类肿瘤抑制基因,成为治疗肿瘤的新靶标.

As a kind of negative regulators, suppressor of cytokine signaling （SOCS） plays an important rolein cells signaling transduction pathways. SOCS can regulate multiple immune responses through inhibiting diverse conduction pathways of the cell factors. Recent studies showed that gene transcription silence which caused by the hypermethylation of SOCS CpG island is closely related to the occurrence of diversiform tu- mors. Thus, as negative regulators of the cell signaling transduction pathways, and also on the behalf of a class of tumor suppressor genes, SOCS are the new targets of tumors therapy.