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右美托嘧啶对脓毒血症大鼠生存率及IL-6、IL-10的影响 被引量：4

Effects of Dexmedetomidine on Survival Rate, IL-6 and IL-10 of Rats with Sepsis
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摘要 目的探讨右美托嘧啶对脓毒血症大鼠生存率及IL-6、IL-10的影响。方法将40只雄性SD大鼠随机分为:假手术组,假手术+右美托嘧啶组,脓毒血症组和脓毒血症+右美托嘧啶组。观察各组大鼠的生存率和血清IL-6、IL-10水平。结果与脓毒血症组相比,右美托嘧啶可明显提高脓毒血症大鼠生存率,降低血清IL-6,升高血清IL-10水平。结论右美托嘧啶可能通过抗炎作用提高脓毒血症大鼠的生存率。 Objective To investigate the influence of dexmedetomidine on the survival rate, IL-6 and IL-10 of rats with sepsis. Methods 40 male SD rats were randomly divided into the follow groups： sham operative group, sham operative ＋dexmedetomidine group, sepsis group, sepsis ＋ dexmedetomidine group. The survival rates as well as the serum IL-6 and IL-10 levels of rats were observed. Results Compared with sepsis group, dexmedetomidine obviously improved the survive rate of rats with sepsis, reduced the serum IL-6 level, and increased the serum IL-10 level. Conclusion Dexmedetomidine may improve the survival rate of septic rats by anti-inflammatory action.
作者 信玉昌 谢克亮 谢红
机构地区 苏州大学附属第二医院麻醉科 天津医科大学总医院麻醉科
出处 《临床医学工程》 2012年第5期710-711,共2页 Clinical Medicine & Engineering
关键词 右美托嘧啶 脓毒血症 IL-6 IL-10 Dexmedetomidine Sepsis IL-6 IL-10
分类号 R965.2 [医药卫生—药理学] R-33 [医药卫生]
  • 相关文献

参考文献7

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二级参考文献10

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共引文献11

同被引文献62

  • 1刘小颖,朱姜华,王沛玉,王薇,钱朝霞,吴新民.不同麻醉用药与不同麻醉方法对术中患者应激反应的影响[J].中华医学杂志,2007,87(15):1025-1029. 被引量：39
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引证文献4

二级引证文献25

临床医学工程
2012年 第5期

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