缺血性脑卒中患者血清炎性细胞因子水平的变化和意义

Changes of Serum Inflammatory Cytokines and Significance in Patients with Ischemic Stroke

目的研究缺血性脑卒患者血清淀粉样蛋白-A(SAA)、白介素-18(IL-18)和C反应蛋白(CRP)水平的变化和意义。方法缺血性脑卒中146例,健康体检者112例,应用酶联免疫吸附(ELISA)方法检测两组研究对象血清SAA、IL-18和CRP水平,应用皮尔逊(Pearson)相关分析法分析缺血性脑卒中患者血清SAA、IL-18水平与CRP的相关性。结果缺血性脑卒中患者血清SAA水平显著高于对照组(t=2.45,P<0.05),SAA与CRP呈显著性正相关(r=0.51,P<0.01)。缺血性脑卒中患者血清IL-18水平显著高于对照组(t=2.64,P<0.01),IL-18与CRP呈显著性正相关(r=0.68,P<0.01)。结论缺血性脑卒中患者SAA、IL-18和CRP等炎性细胞因子在脑组织缺血性损伤中有重要作用。

Objective To investigate serum levels of amyloid A （SAA）, interleukin-18 0L-18） and C-reactive protein （CRP） in patients with ischemic stroke and the significant changes. Methods 146 patients with ischemic stroke and 112 healthy people were selected as case group and control group respectively. The levels of SAA, IL- 18 and CRP in two groups were detected by ELISA. Pearson＇s correlation was used to analyze the correlation between serum levels ofSAA, IL-18 and CRP in case group. Results The SAA levels in case group were significantly higher than those in control group （t = 2.45, P〈0.05）, and SAA was positively correlated to CRP level （r = 0.51, P 〈0.01）. The serum levels of IL- 18 in case group were significantly higher than those in control group （t = 2.64, P〈0.01）, and IL- 18 was positively correlated to CRP level （r = 0.68, P 〈0.01）. Conclusions The inflammatory factors of SAA, IL- 18 and CRP may play an important role in oatients with ischemic stroke.