雷米普利对血流动力学及血管平滑肌的作用

Effects of ramipril on haemodynamics and vascular smooth muscle

雷米普利(Ram)1mg/kg iv能使正常血压大鼠、豚鼠的收缩压(SAP),舒张压(DAP),平均动脉压(MAP)迅速而持久下降,伴有左室压(LVP),左室内压力最大变化速率(±dp/dt_(max))下降,30 min后LVP,±dp/dt_(max)恢复,而血压在90 min后仍明显低于给药前水平。血管紧张素I(ANG I)10μg/kg iv后,上述参数迅速上升,但为时短暂。先iv Ram 1mg/kg,20 min后注入ANG I,以上作用不再出现。 离体实验中,Ram 0.1和1 μmol/L使甲氧明收缩兔胸主动脉和肺动脉环的量效反应曲线平行右移,最大反应压低不明显,求得Ram在主动脉环和肺动脉环上拮抗甲氧明的pA_2值分别为6.48和7.02。

Ramipril(Ram),a renin-angiotensin converting enzyme inhibitor,iv 1 mg/kg lowered rapidly and lastingly SAP,DAP and MAP in the anaesthetized normotensive rats and guinea pigs.During the early hypotensive period,LVP and-dP/dtmax were also reduced but restored to the initial value 30 min later.However,blood pressure was still lowered significantly 90 min later,while LVEDP and HR were not changed.ANG I 10μg/kg iv increased SAP,DAP,MAP,LVP,-dP/dtmax,LVEDP and HR.They were restored to normal in 3-5 min.Pretreatment withRam iv 1 mg/kg,the same dose of ANG I,did not alter the parameters mentioned above.It is suggested that Ram could antagonise the cardiovascular effects of ANGI.In the isolated rabbit aortic and pulmonary artery rings,Ram 0.1-1μmol/L shifted parallelly the dose-response curves of methoxamine to the right with the pA2 values of 6.48 and 7.02,respectively.