“冠心通络舒郁丸”对家兔动脉粥样硬化症血液流变学的作用

The Effect "Guan Xin Tong Luo Shu yu Pill" in Blood Rheology of the Experimental Arteriosclerotic Rabbit

用大耳白兔30只,分三组进行实验。对照组以高胆固醇-高脂肪饮食复制成动脉粥样硬化症模型。服药组除喂以造型剂外加服“冠心通络舒郁丸”,共2_0周。实验结果,服药组与对照组比较,血液流变学得到明显的改善,经统计学处理差异非常显著。

Experimental atherosclerosis was produced by feeding the rabbits with high cholesterol-high fat diet. 30 rabbits were randomly divided into 3 groups of 10 animals. 3 groups were treated for 20 weeks, respectively with (A)nor- mal group-normal diet, (B) control group-high cholesterol-high fat diet and (C) experimental group- (B) diet plus 'Guan xin tong luo shu yu pill'. The blood rheology methods, containing 8 indexes: i. e. whole blood viscosity, plasms viscosity, whole blood reduction viscosity, RBC of electrophoresis, erythrocyte sedimentation rate, hematocrit, erythrocyte equational coefficient K and erythrocyte agglutiation index, were to be, taken at pre-and-post experi ment. At the end to experiment, the hemorrheologic difference between B and C group showed a high significance statistically, the homorrheology of the rab- bit Was significantly ameliorated by the 'Guan xin tong luo sha yu pill'. In the present study, it is suggested that a definite experimental criterion is provided for the clinical use of 'Guan xin tong luo shu yu pill'.