红曲淫羊藿合剂对动脉钙化小鼠脑组织单胺氧化酶-B活性的影响

Effect of monascus mycelia and epimedium mixture on brain monoamine oxidase-B activity in arteriosteogenesis mice

目的观察红曲淫羊藿合剂对动脉钙化小鼠脑组织单胺氧化酶-B(MAO-B)活性的影响。方法联合运用维生素D3和动物油建立动脉钙化小鼠模型,并给予血脂康、红曲菌丝体醇提物、淫羊藿醇提物、红曲淫羊藿合剂等药物进行干预,实验6周后观察体重、胸主动脉形态变化以及测定脑组织MAO-B活性。结果模型组小鼠胸主动脉钙化,脑组织MAO-B活性升高,红曲淫羊藿合剂可显著降低MAO-B活性,而对照药血脂康、红曲菌丝体和淫羊藿对MAO-B活性升高无抑制作用。结论红曲淫羊藿合剂对动脉钙化小鼠脑组织MAO-B活性升高具有显著抑制作用,提示该复方具有延缓衰老和预防神经退行性疾病的作用。

Objective To observe the effects of monascus mycelia and epimedium mixture on brain monoamine oxidase - B activity in arteriosteogenesis mice. Methods Using the combination of Vitamin D3 and animal oil to establish arteriosteogenesis mice model, which were treated with Xuezhikang （ XZK ） , alcohol extract of monascus mycelia （ AEMM ） , alcohol extract of epime- dium （ AEEP } and monascus mycelia and epimedium mixture （ MMEM）. Body weight, morphology changes of thoracic aortas and brain MAO - B was activity were determined after 6 weeks. Results The thoracic aortas was calcified and the activity of brain MAO - B elevated in model mice. MEMM significantly reduced the activity of MAO - B. However,XZK,AEMM and AEEP had no inhibition on the activity of brain MAO - B. Conclusion Monascus mycelia and epimedium mixture can significandy inhibit the activity elevation of brain MAO - B in arteriosteogenesis mice, and this suggested that the compound had the role of delaying se- nescence and preventing neural degenerative diseases.