乙型肝炎后肝硬化患者服用抗病毒药物治疗依从性的调查

Investigation on Antiviral Compliance of Cirrhosis Patients Following Chronic Hepatitis B

目的了解乙型肝炎(下简称"乙肝")后肝硬化患者服用抗病毒药物治疗的依从性。方法方便性抽样选取99例来院就诊的乙肝后肝硬化患者,应用自行设计的问卷对其服用抗病毒药物的依从性进行调查,并对结果进行统计学分析。结果乙肝后肝硬化患者抗病毒治疗依从性欠佳;漏服或停服药的原因包括忘记服药、缺药、禁食、改中药治疗和擅自停药等;对抗病毒治疗相关复查指标的认知度较差;接受健康宣教的患者在漏服药、复查指标明确度和依从性方面与未接受接受健康宣教的患者比较,差异有统计学意义(P<0.05)。结论医护人员要有针对性地对患者进行健康教育,并重视出院随访,从而形成患者从入院-出院-后期随诊的一体化治疗系统,以提高乙肝后肝硬化患者服用抗病毒药物治疗的依从性。

Objective To evaluate the antiviral compliance of cirrhosis patients following chronic hepatitis B. Methods A self-designed questionnaire was used in this Study. Ninety-nine cirrhosis patients following chronic hepatitis B （CHB） were investigated. The results were statistically analyzed. Results The compliance of antiviral therapy in cirrhosis patients following CHB was below the mark. Missing drugs, drug insufficiency, absolute diet, changing the traditional Chinese medicine and unauthorized withdrawal were the main causes of missing antiviral drugs. The awareness of review project for antiviral therapy was worse. Compared with those without health education, these patients who received health education showed significant enhanced awareness of review projects and compliance （P〈0.05）. Conclusion Medical personnel should give targeted health education for patients and emphasize the follow up to patients outside hospital. Establishment of an integrated treatment system including to manage and follow up to hospitalized patients and patients outside hospital will improve compliance of antiviral therapy for cirrhosis patients following CHB.