细胞间黏附分子-1在肝癌发生发展中的表达及作用

Expression and the role of intercellular adhesion molecule-I in theoccurrence and development of hepatoma

细胞间黏附分子-1与肝癌的发生、发展和转移过程密切相关。多种炎症因子及刺激通过核因子-κB信号通路对细胞间黏附分子-1的表达产生影响。在炎症阶段、肝硬化期和肿瘤期，细胞间黏附分子-1通过不同表达对细胞产生不同作用，促进肿瘤的发生与转移。细胞间黏附分子-1对AFP阴性或可疑阳性的肝细胞癌有早期诊断意义，是评估肝癌转移及预后的生物标记。许多治疗肝癌的新方法基于在不同层面对细胞间黏附分子-1的影响进而产生抗肿瘤作用。

Intercellular adhesion molecule -1 is closely related to the occurrence, development and metastasis of liver cancer. A variety of inflammatory cytokines and stimulus effect on the expression of Intercelluar adhesion molecule-1 through Nuclear factor-kappa B signal transduction pathways. In the stage of inflammation, hepatocirrho- sis and tumor, Intereelluar adhesion molecule-1 is expressed differently, and makes different effects on different cells, to promote the occurrence and metastasis of tumor. Diagnostic significance of Intercelluar adhesion molecule- 1 is to diagnose hepatocellular carcinoma with AFP-negative or suspected-positive more early. What＇ s more it can prognosticate the metastasis and prognosis of liver cancer as a biomarker. Many new treatments of liver cancer are based on the effects on Iutercelluar adhesion molecule-1 in different levels producing antitumor function.