Cdx2与食管炎、Barrett’s食管及腺癌的关系

Relationship of Cdx2 with esophagitis, Barrett＇s esophagus andadenocarcinoma

同源异型盒转录因子2是新发现的尾相关同源异型盒转录因子家族中的一个成员，特异地表达于从十二指肠至肛管齿状线的肠道绒毛上皮，在其他空腔脏器黏膜上皮异位表达时可诱导相应部位的肠化生或腺癌发生。在胃十二指肠反流-食管炎一Barrett’s食管一食管腺癌演化过程中，同源异型盒转录因子2起着重要的调控作用，并与p63基因、维甲酸、MUC2、骨形态发生蛋白4等多因素共同作用促进了这一过程的发展。

Caudal-type homeoboxgene transcription factor 2 is one member of the caudal- related homeobox fami- ly, is a transcription factors important in intestinal epithelial development and in the differentiation and maintenance of the intestinal phenotype. In adulthood, these two proteins are strictly confined to the gut and are predominantly expressed by the epithelium of the small intestine and colon, but not by the normal epithelium of the oesophagus and stomach. In intestinal metaplasia, caudal-type homeoboxgene transcription factor 2 upregulation can be a direct effect of injurious agents on epithelial cells and/or can be due to the inflammatory environment of EpM, exposure to acid and/or bile acids may activate caudal-type homeoboxgene transcription factor 2 expression in human esophageal epithelial cells through promoter demethylation, and ectopic caudal-type homeoboxgene transcription factor 2 expres- sion in esophageal squamous epithelia. It has been suggested to play an important role with retinoic acid, MUC2, p63 gene, BMP4 and many other factors working together to promote the development of this process in intestinal metaplasia and cancers.