比较不同剂量芬太尼与舒芬太尼对压力反射敏感性的改变

Effects of Fentanyl and Sufentanil on Baroreflex Sensitivity in Pre-operative Patients

目的:探讨不同剂量芬太尼和舒芬太尼对术前压力反射敏感性(BRS)的影响。方法:选取本院收治的72例全麻剖胸手术患者,随机分为舒芬太尼组和芬太尼组各36例。两组内根据不同剂量再进行分组,舒芬太尼组分为SI组、SII组、SIII组各12例,舒芬太尼的药剂量分别为0.2、0.4、0.6μg/kg。芬太尼组分为FI组、FII组、FIII组各12例,芬太尼的药剂量分别为2、4、6μg/kg。在注药前和注药后分别记录BRS,对各组BRS的变化进行比较。结果:FI、FII、SI组注药后的BRS略低于注药前,差异无统计学意义(P>0.05)。FIII、SII、SIII组注药后的BRS明显低于注药前,差异有统计学意义(P<0.05)。结论:舒芬太尼和芬太尼均能起到抑制压力反射的作用,当舒芬太尼的药剂量大于0.4μg/kg或芬太尼的药剂量大于6μg/kg时效果最显著。在等效剂量的情况下,舒芬太尼组抑制压力反射的效果明显优于芬太尼组。

Objective ：To explore the effects of fentanyl and sufentanil on baroreflex sensitivity in pre-operative patients.Methods ：72 patients with thoracic surgery were collected.The cases were divided into the Sufentanil group （group S） and the Fentanyl group （group F） randomly with each group 36 cases.Each group was divided into three subgroups by different doses. Group SⅠ sutentanil 0.2 μg/kg ; group SⅡ sutentanil 0.4 μg/kg ; group SIII sutentanil 0.6 μg/kg ; group FI tentanyl 2 μg/kg ; group FII tentanyl 4 μg/kg ; group FⅢ tentanyl 6 μg/kg.BRS were measured before and after Fentanyl or sufentanil infusion.The changes of BRS in each group were compared.Results：The BRS in group FⅠ, group FⅡ and group SI were reduced a little （P〉0.05）.The BRS in group FIII, group SⅡ and group SⅢ were reduced much, the difference was statistically significant（P〈0.05）. Conclusion：Fentanyl and sufentanil can decrease the BRS.Fentanyl（〉6 trg/kg） or sufentanil（〉0.4μg/kg） decrease BRS much. In the situation of equipotent dose, the Sufentanil group was better than the Fentanyl group on baroreflex sensitivity.