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结肠癌组织中miR-451表达的检测与分析 被引量：4

Study on the Expression of MicroRNA-451 in Colon Cancer Tissues
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摘要 目的研究结肠癌组织和癌旁组织中miR-451的表达差异。方法分别使用miRNA芯片和Re-al-time PCR检测结肠癌组织和癌旁组织中miR-451。结果 miRNA芯片检测发现结肠癌组织中miR-451相对于癌旁组织表达显著上调,并被Real-time PCR所证实。结论结肠癌组织中miR-451表达上调。 Objective To study expression difference of microRNA-451 between colon cancer tissues and adjacent colon cancer tissues. Methods The expression level of miR-451 in colon cancer tissues and adjacent colon cancer tis- sues was detected by Chip-array and Real-time PCR differently. Results The expression level of miR-451 was signifi- cantly up-regulated in colon cancer tissues comparing to adjacent colon cancer tissues and validated by Real-time PCR. Conclusion Expression level of miR-451 is up-regulated in colon cancer tissues.
作者 谢海涛
机构地区 南华大学附属第一医院检验科
出处 《中南医学科学杂志》 CAS 2012年第3期257-259,共3页 Medical Science Journal of Central South China
关键词 结肠癌 miR-451 MIRNA colon cancer miR-451 microRNA
分类号 R735.35 [医药卫生—肿瘤]
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参考文献6

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共引文献17

同被引文献64

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引证文献4

二级引证文献7

中南医学科学杂志
2012年 第3期

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