奥沙利铂联合5-FU和CF术前治疗直肠癌28例疗效观察

Evaluate the Effect of Preoperative Chemotherapy Oxaliplatin Combined With 5-FU and CF in 28 Patients of Rectal Cancer

目的观察奥沙利铂联合5-氟尿嘧啶(5-FU)、亚叶酸钙(CF)术前治疗直肠癌患者的疗效。方法直肠癌患者60例分为联合化疗组(28例)和单纯化疗组(32例)。联合化疗组治疗方案采用奥沙利铂、5-氟尿嘧啶及亚叶酸钙术前联合化疗;单纯化疗组治疗方案采用5-氟尿嘧啶、亚叶酸钙术前化疗。两组患者均接受3周期化疗,依据WHO推荐的实体瘤疗效评价标准比较两组肿瘤近期疗效;手术后标本按Wheeler的直肠癌消退分级判定比较两组直肠癌肿瘤消退情况。结果实体瘤疗效联合化疗组总有效率64%(18例),单纯化疗组总有效率19%(6例),两组比较差异有显著性(P<0.05)。直肠癌肿瘤消退联合化疗组总有效率79%(22例),单纯化疗组总有效率34%(11例),两组比较差异有显著性(P<0.05)。结论奥沙利铂联合5-FU、CF治疗直肠癌比单纯5-FU、CF术前化疗能明显缩小肿瘤体积,显著消退肿瘤细胞。

Objective To evaluate the effect of preoperative chemotherapy in combination with Oxaliplatin, fluorou- racil（5-FU） and Calcium Folinate（CF） in rectal cancer patients. Methods 60 patients with rectal cancer were divided into combined chemotherapy group（28 eases）and simple chemotherapy group（32 cases）. The three drugs of Oxaliplatin,5- FU and CF were administrated to combined chemotherapy group and the drugs of 5-FU and CF were administrated to simple chemotherapy group before surgery. All patients were treated with three cycles of chemotherapy based on evaluation criteria of the solid tumors according to WHO criterion. Post-operative specimens dissipated by Wheeler Rectal Cancer Regression Grade. The mass tumor efficacy and rectal cancer regression were compared between the two groups. Results The total effective rate of combined chemotherapy group was 64 % （ 18 cases） ,and that in the simple chemotherapy group was 19% （6 cases ）, moreover, there was significant difference in two groups （P 〈 0.05 ）. the total effective rate of mass tumor regres- sion in the combined chemotherapy group was 79% （22 cases ） , and that in the simple chemotherapy group was 34% （11 cases）, the difference between the two groups was significant（ P 〈 0.05 ）. Conclusion Combined treatment of Oxaliplatin with 5-FU, CF obviously reduced tumor mass and cancer cell regression than that of chemotherapy with 5-FU and CF.