抛物线拟合法研究氮酮促进5-氟尿嘧啶透皮吸收的最佳浓度

The best concentration of azone on transdermal absorption of 5-fluorouracil by parabotic curve fitting method

本文以5-氟尿嘧啶(5-Fu)为模型药物,简单小室为实验装置,紫外分光光度法测定5-Fu浓度,采用抛物线拟合法建立了不同时间下氮酮(azone)浓度对5-Fu透皮吸收率的数学模型,用此模型准确求得了azone对5-Fu透皮吸收的最佳浓度为4.14±0.37%。同时证明azone对5-Fu有显著的透皮吸收作用,3%azone24h后对5-Fu透皮吸收作用增强近70%。此研究对提高5-Fu外用制剂的透皮吸收率及临床用于皮肤癌和一些真菌感染的治疗有非常重要的指导意义。

5-Fu was used as a model drug, andsimple cell as an experimental apparatus. The5-Fu concentration was determined by the UVspectrophotometry. The methematic model of5-Fu transdermal absorbed-rate under dif-ferent azone concentrations was calculatedby the parabolic curve fitting method. The bestconcentration of azone on transdermal absor-ption of 5-Fu was 4.14+0.37- Cutaneouspenetration effect of 5-Fu exerted by azonewas significant. With 3% azone, the trans-dermal absorbtion rate of 5-Fu in 24 hoursincreased by about 70%.