双歧杆菌三联活菌联合5-氨基水杨酸治疗溃疡性结肠炎的临床观察

The effects of double branch bacilli triplex viable bacteria combined with 5-aminosalicylic acid on ulcerative colitis and the serum levels of IL-1 and IL-4

目的:探讨双歧杆菌三联活菌联合5-氨基水杨酸对溃疡性结肠炎(UC)的临床疗效以及对血清白细胞介素-1(IL-1)和IL-4的影响。方法:将77例UC患者随机分为5-氨基水杨酸组38例(对照组)和5-氨基水杨酸联合双歧杆菌三联活菌治疗组39例(观察组);治疗6周后,观察临床症状改变以及治疗前后两组血清中IL-1和IL-4的表达变化。结果:观察组总有效率高于改善情况明显优于对照组,表现为腹痛、腹泻、黏液脓血便症状好转或消失。观察组患者血清IL-1降低水平、血清IL-4升高水平与对照组(P<0.05),血清IL-4升高水平较对照组升高明显(P<0.05)。结论:双歧杆菌三联活菌联合5-氨基水杨酸治疗UC疗效肯定,同时双歧三联活菌有助于逆转Th1和Th2细胞的失衡状态。

Objective：To explore the effects of double branch bacilli triplex viable bacteria combined with 5-amino acid on ulcerative colitis（UC） and the serum levels of IL-1 and IL-4. Methods：Seventy-seven cases with UC were randomly divided into 5-aminosalicylic acid group（control group,38 cases） and 5-aminosalicylic acid combined with double branch bacilli triplex viable bacteria group（observation group,39 cases）.The clinical symptoms and the serum levels of IL-1 and IL-4 were evaluated at 6 weeks after treatment. Results：Compared with the control group,the clinical symptoms of observation group were significantly improved（P0.05）,and serum levels of IL-1 and IL-4 significantly decreased and increased（P0.05）. Conclusions：The effects of double branch bacilli triplex viable bacteria combined with 5-aminosalicylic acid on UC are good,can adjust the imbalance of Th1/Th2 cells.