必兰在牙科手术中的镇痛效果与不良反应观察

Observation on Analgesic Effect and Adverse Reaction of Primacaine Adrenaline in the Dental Operation

目的:通过临床观察和比较,评价阿替卡因肾上腺素注射液(必兰)的临床应用效果。方法:将790例病例共1 098颗牙分为实验组和对照组,分别使用必兰和利多卡因麻醉,进行牙髓治疗、活髓基牙预备和拔牙。采用视觉模拟量表(VAS)和语言评价量表(VRS),评价两者注射时患者的疼痛程度和镇痛效果,并记录产生的不良反应。结果:与对照组相比,实验组患者浸润麻醉和阻滞麻醉时的注射疼痛程度均显著降低(P<0.01);且无论牙髓治疗、活髓基牙预备或拔牙,必兰的镇痛效果也更好。两组均无严重不良反应发生。结论:使用必兰局部麻醉时,无明显注射时疼痛、镇痛效果显著、麻醉时间保证、手术视野清晰、不良反应少,是一种安全可靠、可在临床普遍推广使用的口腔局部麻醉药。

Objective：To evaluate the clinical effect of Articaine Hydrochloride and Epinephrine Tartrate Injection（Primacaine Adrenaline） through clinical observation and comparison.Methods：790 Cases（1 098 teeth） were divided into two groups and were anaesthetized respectively by Primacaine Adrenaline and lidocaine to make pulp therapy,vital abutment preparation and tooth extraction.The pain degree and analgesic effect of the two groups were compared through visual analogue scale and verbal rating scale,and the adverse reactions in two groups were recorded as well.Results：Compared with lidocaine,injection pain of Primacaine Adrenaline was significantly decreased（P0.01） during infiltration anesthesia and block anesthesia,and the analgesic effect of Primacaine Adrenaline in tooth extraction,pulp therapy and vital abutment preparation was better.No severe adverse reaction was observed both in Primacaine Adrenaline group and in lidocaine group.Conclusion：The use of Primacaine Adrenaline in anesthesia led to obvious analgesic effect,sufficient anesthesia time,clearoperational visual field and fewer adverse reactions without any apparent aches.Therefore,Primacaine Adrenaline is safe and reliable,which can be widely used in oral local anesthetics clinically.