萘普生及其钠盐栓剂的生物利用度

Bioavailability of suppositories of naproxen and its sodium salt

以尿药排泄速率法在6名健康志愿受试者中进行了萘普生及其钠盐栓剂的生物利用度测定。以萘普生片剂为参比标准,2种栓剂的相对生物利用度分别为93%和124%。对3种制剂的有关参数进行方差分析,结果表明Xu和Tm在三者之间无显著差异(P>0.05)。

The bioavailability of naproxen and its sodiumsalt suppositories were studied by the urine drugexcretion rate in six health volunteers. The relativebioavailability of the two suppositories were 93% and124% respectively; tablet of naproxen was used asthe reference standard. The results of variance para-meters of the three preparations indicate no signifi-cant difference with each other (P>0.05)