cathepsin B和cystatin C在人脑胶质瘤中的表达及意义

Expression and significance of Cathepsin B and Cystatin C in human gliomas

目的探讨半胱蛋白酶抑制剂C(cystatin C)和组织蛋白酶B(cathepsin B)在人脑胶质瘤组织中的表达及意义。方法通过免疫组织化学法检测cystatin C及cathepsin B在57例不同分化程度的脑胶质瘤组织中的表达。结果cystatin C在低分化胶质瘤(III-IV级)中的表达低于高分化者(I～II级),而cathepsin B在低分化胶质瘤中的表达高于高分化者(P<0.05)。cystatin C和cathepsin B在脑胶质瘤中的表达呈负相关(P=0.01)。结论 cystatin C和cathepsin B的表达与人脑胶质瘤病理分级及侵袭性相关。联合检测cystatin C和cathepsin B的表达,可为脑胶质瘤的侵袭性及临床恶性程度评估提供重要信息。

Objective To explore the expression and significance of cystatin C and cathepsin B in human gliomas.Methods A immunohistochemical method was used to detect the expression of cystatin C and cathepsin B in 57 glioma samples.Results The expression of cystatin C in high-grade（Grade III-IV）gliomas was significantly weaker than that in low-grade（Grade I-II）.On the other hand,the expression of cathepsin B in high-grade gliomas was significantly stronger than that in low-grade（P〈0.05）.Cystatin C expression correlated inversely with cathepsin B expression in gliomas（P=0.01）.Conclusion Cystatin C and cathepsin B expression is related to the pathological grade and invasion of gliomas.Combining detection of cystatin C and cathepsin B expressions might provide significant information for clinical assessment of maglignant phenotypes and invasion of gliomas.