含铋剂四联疗法根除幽门螺杆菌疗效观察

Clinical study of eradication of helicobacter pylori with bismuth-based quadruple therapy

目的探讨含铋剂四联疗法治疗消化性溃疡Hp感染初治者的疗效。方法将138例消化性溃疡Hp感染初治者随机分成治疗组和对照组。治疗组70例患者给予胶体果胶铋+泮托拉唑+克拉霉素+阿莫西林;对照组68例患者给予泮托拉唑+克拉霉素+阿莫西林。两组患者均完成1周治疗,治疗结束后4周对根除Hp的疗效进行观察。结果治疗组和对照组Hp根除率分别为87.14%(61/70)和73.53%(50/68),差异有统计学意义(χ2=4.06,P<0.05)。结论含铋剂四联疗法用于消化性溃疡Hp感染初治者的疗效好于标准三联疗法。

Objective To observe the effect of eradicating helicobacter pylori（Hp） with bismuth-based quadruple therapy on treating peptic ulcer. Methods A total of 138 patients with peptic ulcer and Hp infection were allocated to two groups. The treatment group （n =70） received colloidal bismuth pectin 200rag bid,pantoprazole 40rag bid, amoxicillin 1.0g bid and clarithto- mycin 500mg bid for 7 days; the control group received pantoprazole 40mg bid , amoxicillin I. 0 g hid and clarithromycin 500mg bid for 7 days. Following the treatment, x4 C urea breath test was performed to observe the Hp eradication rate. Results The eradi- cation rate of bismuth-based quadruple therapy was 87. 14%, and that of comml group was 73.53%. The difference between two groups was significant（P 〈 0. 05 ）. Conclusion Compared to the standard triple therapy regimen,the bismuth-containing quadruple therapy regimen has higher eradication rate.