急性有机磷中毒使用长托宁和阿托品临床80例分析

Clinical analysis of acute organophosphate poisoning using atropine and penehyclidine hydrochloride atropine about 80 cases

目的探讨在急性有机磷中毒时使用长托宁(盐酸戊乙奎醚)对阿托品剂量、时间使用的影响。方法将我院自2003～2009年共收治80例急性有机磷中毒患者分为对照组和治疗组。治疗组为阿托品、碘解磷定加长托宁,对照组为常规使用使用阿托品、碘解磷定组,分析两组患者阿托品用量、维持时间及病死率。结果长托宁可以使轻、中、重急性有机磷中毒患者减少阿托品用药总量,治疗组分别为15、76、101mg,对照组分别为43、83、840mg减少阿托品用药次数,治疗组分别为:15、23、30次,对照组分别为:20、35、94次,缩短阿托品化时间,治疗组分别为:1.5、3、5h,对照组分别为:3、5、8h,缩短治愈时间:治疗组分别为:3、4、5d,对照组分别为:4、5、6d,两组比较差异有统计学意义。结论急性有机磷中毒配合使用长托宁,减少阿托品使用总量及维持时间,并且不易发生反跳,病死率降低,长托宁是一种比阿托品效果好、不良反应少的新型抗胆碱能药。

Objective To explore in acute organophosphate poisoning “to use long temple, use of atropine doses. Methods From 2003 - 2009 1995,23 cases of acute organophosphate poisoning 80 cases of patients in the eontrul group and divided into treatment group, the treatment group for atropine and recent iodine, torte for extended for routine use of atropine in recent, iodine, analyzes two groups for group patients maintain time and atropine, mortality. Results Torre would make long mild, moderate, and severe acute organophosphate poisoning patients reduce total drug treatment group and atropine 15rag respectively, 76mg, 101mg, respectively, in 43mg 83mg, 840mg reduce atropine, drug treatment group is respectively： 15 times, 23 times, 30 times, respectively is： 20 times, 35, 94, shorten the time of atropine, the treatment group is respectively Z 1, 5h 5h and control, 3h, respectively, the 5h and 8h： 3h, shorten the time： treatment group cure for three days, respectively, 4 days, 4 days, respectively is ： 4 days, five days, six days, two groups of comparisons have significant differences, Conclusion Acute organophosphate poisoning with long, reduce use “total and maintain time atropine, and not long river, lower mortality,”rather than is a good effect and atropine adverse reaction of new anticholinergic medicines.