盐酸布比卡因与青霉素类药物配伍实验及临床解痛效果观察

The compatibility of bupivacaine HCI with penicillins

盐酸布比卡因局麻作用强而持久,毒性低,本文将肌肉注射后引起疼痛的5种青霉素类抗生素粉针剂,用0.1%盐酸布比卡因注射液作为解痛剂做溶媒,经配伍实验和含量测定,结果表明无理化性配伍禁忌。经临床使用均取得了良好的解病效果。并以青霉素钠为代表进行了生物利用度测定,结果证明0.1%盐酸布比卡因注射液对青霉素钠在体内药物动力学过程无影响。另氨苄青霉素钠与盐酸布比卡因注射液配伍后发现有理化性配伍禁忌,未用于临床。

Bupivacaine HCl injection (0.1%) is used as asolvent to dissolve 5 kinds of penicillins for thepurpose in relief of pain in intramuscular administra-tion. Bupivacaine HCl can be compatible withpenicillin Gsodium, potassium, oxacillin sodium andcarbencillin disodium but incompatible with ampici-llin sodoium. 0.1% bupivacaine HCl injection canrelieve the pain caused by penicillins on intramus-cular administration and has no influence on phar-macokinetics of penicillin G sodium.