吩噻嗪类对精神分裂症患者血清高密度脂蛋白及其亚组分中胆固醇含量的影响

High density lipoprotin cholesterol and subfraction in schizophrenic patients after phenothrenic treatment

本文对长时间(平均5～6年)接受吩噻嗪类药物治疗的慢性精神分裂症患者血清HDL及其亚组分中胆固醇含量进行了分析。结果显示:精神分裂症病人HDL-C水平比正常对照组明显降低(P<0.005),其HDL亚组分变化主要表现在HDL_3-C显著性降低(P<0.001),而HDL_2-C不降低。作者认为:吩噻嗪类药物能引起HDL-C水平降低,并对可能作用机制进行了探讨。

The concentrations of high density lipoproteincholesterol and subfraction were investigated in pati-ents receiving phenothiazine for long periods (average5～6 years). The results showed that high densityliporotein cholesterol(HDL-C) levels were significantlylower(P<0.005) in the patients than in the normalcontrol. The HDL subfraction indicated that HDL-Cwas significantly lower(P<0.001) in the patients thanthe normal control, whereas HDL-C was not. Wesuggest that significantly low HDL-C level may becaused after the administration of phenothiazine.The mechanism of HDL-C lowering is discussed.