艾塞那肽治疗对2型糖尿病患者缓解期的影响研究

Effects of Exenatide Treatment on Remission Period of Patients with Type 2 Diabetes

目的:研究艾塞那肽治疗对2型糖尿病患者缓解期的影响。方法:选择2009年11月-2010年10月我院内分泌科收治的57例2型糖尿病患者为研究对象,按照病程、体重指数、空腹餐后C肽、血脂、原有治疗方案一一配对分成艾塞那肽组(n=31)与对照组(n=26)。共治疗3个月,每月随访1次,检测血糖、糖化血红蛋白(HbA1c)、C肽、胰岛素,治疗前与治疗3个月后行72h动态血糖监测、静脉葡萄糖耐量试验。结果:艾塞那肽治疗3个月,16.13%(n=5)的2型糖尿病患者出现缓解期,与对照组比较差异有统计学意义(P<0.05);与治疗前比较,艾塞那肽治疗3个月的空腹血糖、餐后血糖、HbA1c下降,高血糖及低血糖所占时间比下降,差异有统计学意义(P<0.05)。结论:艾塞那肽治疗可促进2型糖尿病患者出现缓解期。

OBJECTIVE：To investigate the effects of exenatide treatment on the remission period of patients with type 2 diabetes.METHODS：57 patients with type 2 diabetes in endocrinology department of our hospital from Nov.2009 to Oct.2010 were included and divided into exenatide group （n=31） and control group （n=26） according to disease duration,body weight index,fasting postprandial C Peptide,blood lipid,previous treatment scheme.During follow-up,plasma glucose,HbA1c,serum insulin and C peptide were evaluated every month.Before treatment and after 3 month,72 h dynamic glucose monitoring （DGM） and intravenous glucose tolerance test （IVGTT） were performed.RESULTS：In type 2 diabetics with the treatment of exenatide,16.13% （n=5） of them achieved remission,there was statistical significance between exenatide group and control group （P〈0.05）.Compared with before treatment,fasting blood glucose,postprandial blood glucose,HbA1c and the rate of hyperglycemia and hypoglycemia during DGM were significantly lowered after 3 months of treatment,there was statistical significance （P〈0.05）.CONCLUSION：Exenatide therapy can promote remission of patients with type 2 diabetes.