2所不同国家医院剖宫产围术期抗生素预防性应用比较

Comparison of Perioperative Prophylactic Application of Antibiotics for Cesarean Section between Two Hospitals from Different Countries

目的:探讨有效、合理、方便、经济的剖宫产围术期抗生素预防性用药方案。方法:2所医院170例剖宫产者采用2种不同的用药方案,其中2011年摩洛哥拉西迪亚省立医院妇产科85例设为Ⅰ组,产妇在术中断脐后静脉点滴氨苄青霉素2.0g,术后氨苄青霉素1.0g,q6h,给药4次;2011年上海市长宁区中心医院产科85例设为Ⅱ组,术前30min静脉点滴头孢唑林1.0g,术后头孢唑林1.0g,q12h,持续3d。比较2组术后发热、产褥病率、伤口愈合情况、产后恢复和预防感染的效果。结果:Ⅰ组的抗生素用药剂量少、用药时间短、术后恢复快,预防感染效果与Ⅱ组相同。结论:Ⅰ组方案优于Ⅱ组。

OBJECTIVE：To investigate effective,rational,convenient and economic program of perioperative prophylactic application of antibiotics in cesarean section.METHODS：170 cases of cesarean section in 2 hospitals were given two kinds of drug regimens,among which 85 cases of pregnant women from Morocco Rachidia Provincial Hospital as groupⅠwere given ampicillin 2.0 g i.v.gtt after cutting off the umbilical cord during operation,and given ampicillin 1.0 g i.v.gtt,q6h,4 times after operation;85 cases of pregnant women from Shanghai Changning District Central Hospital as groupⅡwere given cefazolin 1.0 g i.v.gtt 30 min before operation and cefazolin 1.0 g i.v.gtt,q12h for consecutive 3 d after operation.The postoperative fever,postoperative puerperal morbidity,postoperative wound healing,postpartum recovery and the effect of infection prevention were compared between two groups.RESULTS：GroupⅠshowed small amount of antibiotics used,short medication time and rapid postoperative recovery,and the effect of infection prevention was the same as groupⅡ.CONCLUSION：The regimen of groupⅠis better than groupⅡ.