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信号通路在卵巢癌中的新研究进展 被引量:2

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摘要 卵巢癌是一类易于转移,并且易于广泛播散的恶性肿瘤,其发生率在女性生殖系统肿瘤中占第3位,仅仅低于宫颈癌和子宫内膜癌,但其病死率却是最高,是妇科恶性肿瘤死亡的主要原因。70%的卵巢癌病例在就诊时已经属于晚期,5年生存率仍然徘徊在20%~30%。
出处 《世界中西医结合杂志》 2012年第5期448-450,共3页 World Journal of Integrated Traditional and Western Medicine
基金 教育部春晖计划(No.Z2007-1-15001) 黑龙江省自然科学基金(No.D200816) 黑龙江中医药大学杰出人才基金项目(No.200703)
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同被引文献20

  • 1刘爱军,韦立新,李亚里.卵巢癌分子靶向治疗的研究进展[J].中华临床医师杂志(电子版),2011,5(7):2008-2011. 被引量:13
  • 2Siegel R, Ward E, Brawley O,et al. Cancer statistics,2011 :The im- paet of eliminating socioecnnomic and racial disparities on premature cancer deaths[J]. CA Cancer J Clin,2011,61 (4) :212 -236.
  • 3hamochi H, Kigawa J. Clinical trials and future potential of targeted therapy for ovarian cancer [ J ]. lnt J Clin Oncol, 2012, 17 (5) : 430 - 440.
  • 4Diaz-Padilla I, Duran l,Clarke BA,et al. Biologic rationale and clini- cal activity of roTOR inhibitors in gynecological cancer [ J ]. Cancer Treat Rev ,2012,38 ( 6 ) : 767 - 775.
  • 5Matmchi S, Kawase C, Ahomare DA,et al. mTOR is a promising tiler- apeutic target both in cisplatin-sensitive and cisplatin-rcsistant clear cell carcinoma of the ovary[ J ]. Clin Cancer Res ,2009,15 ( 17 ) :5404 - 5413.
  • 6Lau MT, Leung PC. The PI3 K/Akt/mTOR signaling pathway mediates insulin-like growth factor l-induced E-cadherin down-regulation and cell proliferation in ovarian cancer cells[J]. Cancer Lett, 2012,326 (2) :191 -198.
  • 7Huang J,Zhang L. Frequent genetic abnormalities of the PI3K/AKT pathway in primary ovarian cancer predict patient outcome[ J ]. Genes Chromosomes Cancer,2011,50 ( 8 ) :606 - 618.
  • 8Michael Hpfner,Detlef Schuppan,Hans Scherübl.Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular cancer[J].World Journal of Gastroenterology,2008,14(1):1-14. 被引量:33
  • 9陈爱平,杨蕊蕊,张红玲,宋慧.EGFR、VEGF及LRP mRNA在卵巢上皮性癌组织中的表达及其意义[J].现代妇产科进展,2008,17(10):748-751. 被引量:7
  • 10朱颖军,高企贤.PI3K/Akt/mTOR信号转导通路与卵巢癌研究进展[J].国际妇产科学杂志,2009,36(2):135-139. 被引量:7

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