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多囊卵巢综合征与表观遗传学的最新研究进展 被引量：5

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摘要 多囊卵巢综合征（PCOS）是育龄妇女常见的内分泌疾病,其发病率约占7%～10%。PCOS表现了遗传异质性、发病多因性、种族差异性、临床表现多样性等特征。此外,它还能引起糖尿病、冠状动脉心脏病和癌症,也可导致不孕,对人体造成严重的影响。多囊卵巢综合征可以被看作是一个具有不同异构雄激素多个基因和环境因素,种族差异相互作用决定的生殖和代谢异常的内分泌疾病。
作者 沈欢欢 张多加 李晶 韩学静 吴效科
机构地区 黑龙江中医药大学
出处 《世界中西医结合杂志》 2012年第5期451-454,共4页 World Journal of Integrated Traditional and Western Medicine
基金 黑龙江省教育厅科研项目(No.12511498)
关键词 多囊卵巢综合征(PCOS) 表观遗传学 病因学 种族差异 环境
分类号 R711.75 [医药卫生—妇产科学]
  • 相关文献

参考文献30

  • 1Abbott DH,Dumesic DA,Franks S.Developmental origin of polycystic ovary syndrome-a hypothesis[J].J Endocrinol,2002,174(1):1-5.
  • 2Gambineri A,Pelusi C,Vicennati V,et al.Obesity and the polycystic ovary syndrome[J].Int J Obes Relat Metab Disord,2002,26(7):883-896.
  • 3翟军,阮祥燕.多囊卵巢综合征临床治疗进展[J].实用妇产科杂志,2004,20(2):74-76. 被引量：23
  • 4Dasgupta S,Reddy BM.Present status of understanding on the genetic etiology of polycystic ovary syndrome[J].J Postgrad Med,2008,54(2):115-125.
  • 5Norman RJ,Davies MJ,Lord J,et al.The role of lifestyle modification in polycystic ovary syndrome[J].Trends Endocrinol Metab,2002,13(6):251-257.
  • 6Williamson K,Gunn AJ,Johnson N,et al.The impact of ethnicity on the presentation of polycystic ovarian syndrome[J].Aust N Z J Obstet Gynaecol,2001,41(2):202-206.
  • 7Yavasoglu I,Kucuk M,Cildag B,et al.A nove association between polycystic ovary syndrome and Helicobacter pylori[J].Am J Med Sci,2009,338(3):174-177.
  • 8Wijeyaratne CN,Balen AH,Barth JH,et al.Clinical manifestations and insulin resistance(IR)in polycystic ovary syndrome(PCOS)among South Asians and Caucasians:Is there a difference?[J].Clin Endocrinol(Oxf),2002,57(3):343-350.
  • 9Calvo RM,Tellería D,Sancho J,et al.Insulin gene variable number of tandem repeats regulatory polymorphism is not associated with hyperandrogenism in Spanish women[J].Fertil Steril,2002,77(4):666-668.
  • 10Vink J,Sadrzadeh S,Lambalk CB,et al.Heritability of polycystic ovary syndrome in a Dutch twin-family study[J].J Clin Endocrinol Metab,2006,91(6):2100-2104.

二级参考文献17

  • 1[1]Michael J, Slowey MD,Concord NC.Polycystic ovary syndrome :New perspective on old problem . Southern Medical Journal , 2001, 94(2):190-196.
  • 2[2]Ajossa S, Guerriero S, Paolelti AM, et al .The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome. Fertil Steril, 2002,77(6): 1136-1140.
  • 3[3]George Mastorakos G, Koliopoulos C, Creatsas G. Androgen and lipid profiles in adolescents with polycystic ovary syndrome who were treated with two forms of combined oral contraceptives. Fertil Steril, 2002,77(5):919-927.
  • 4[4]Telli MH , Yildirim M, Noyan V, et al. Serum leptin levels in patients with polycystic ovary syndrome. Fertil Steril, 2002, 77(5): 932-935.
  • 5[5]Diamanti-Kandarakis E, Spina G, Kouli C, et al. Imcreased endothelin -I levels in women with polycystic ovary syndrome and the beneficial effect of meformin therapy. J Clin Endocrinol Metab ,2001, 86(10):4666-4673.
  • 6[6]Vandermolen DT, Ratts VS, Evans WS, et al .Metformin increases the ovulatory rate and pregnancy rate with clomiphene citrate in patients with polycystic ovary syndrome who are resistant to clomiphene citrate alone. Fertil Steril , 2001,75(3):310-315.
  • 7[7]Ng EH, Wat NM, Ho PC. Effects of metformin on ovulation rate, hormonal and metabolic profiles in women with clomiphene resistant polycystic ovaries: a randomized,double-blinded placebo-controlled trial. Hum Reprod, 2001,16(8): 1625-1631.
  • 8[8]De Leo V, La Maca A, Ditto A, et al. Effects of metformin on gonadotropin -induced ovulation women with polysystic ovary syndrome. Fertil Steril, 1999, 72(2):282-285.
  • 9[9]Jakubowicz DJ, Iuorno MJ, Jakubowicz S, et al. Effects of metformin on early pregnancy loss in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2002,87(2): 524-529.
  • 10[10]Glueck CJ, Wang P, Kobayashi S, et al. Metformin therapy throughout pregnancy reduces the development of gestational diabetes in women with polycystic ovary syndrome. Fertil Steril, 2002,77(3): 520-525.

共引文献22

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二级引证文献29

世界中西医结合杂志
2012年 第5期

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