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动脉导管未闭形成的分子机制 被引量：5

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摘要 动脉导管未闭(PDA)是最常见的小儿先天性心脏病之一,动脉导管的关闭过程涉及到血管平滑肌细胞(VSMCs)的增殖和迁移、内膜垫的形成、血管的收缩和重构等多个环节。研究表明前列腺素E(PGE)、环氧合酶(COX)、MHY11、Jag1、TFAP2B等基因的表达产物参与了动脉导管闭合的多个环节,以上这些基因的异常往往导致了PDA的形成。
作者 吉炜 李奋
机构地区 上海交通大学医学院附属上海儿童医学中心心内科
出处 《国际心血管病杂志》 2012年第3期141-143,共3页 International Journal of Cardiovascular Disease
关键词 动脉导管未闭 分子机制 基因 信号通路
分类号 R541.1 [医药卫生—心血管疾病]
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参考文献22

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  • 2Yokoyama U, Minamisawa S, Ishikawa Y. Regulation of vascular tone and remodeling of the ductus arteriosus[J]. J Smooth Muscle Res,2010,46(2) :77-87.
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  • 5Coggins KG, Latour A, Nguyen MS, et al. Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus[J]. Nat Med, 2002,8 (2) 91-92.
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  • 7Yokoyama U, Minamisawa S, Quan H, et al. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan- mediated neointimal formation in the ductus arteriosus[J]. JClin Invest,2006,116(11):3026- 3034.
  • 8Jones LJ, Craven PD, Attia J, et al. Network meta analysis of indomethacin versus ibuprofen versus placebo for PDA in preterm infants[J].Arch Dis Child Fetal Neonatal Ed,2011, 96(1) : F45-F52.
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同被引文献39

  • 1Schneider DJ,Moore JW. Patent ductus arteriosus [ J ]. Circula-.ion,2006;114:1873 -1882.
  • 2Yokoyama U, Minamisawa S, Ishikawa Y. Regulation of vasculartone and remodeling of the ductus arteriosus[ J]. J Smooth MuscleRes,2010 ;46 :11 -87.
  • 3Kajino H, Goldbarg S, Roman C, et al. Vasa vasorum hypoperfu-sion is responsible for medial hypoxia and anatomic remodeling inthe newborn lamb ductus arteriosus[ J]. Pediatr Res,2002;51:228-235.
  • 4Momma K,Nishihara S,Ota Y. Constriction of the fetal ductus arte-riosus by glucocorticoid hormones[ J]. Pediatr Res, 1981 ; 15 : 19 —21.
  • 5Chiruvolu A,Jaleel MA. Therapeutic management of patent ductusarteriosus[ J] . Early Hum Dev,2009 ;85 :151 - 155.
  • 6Goumay V,Roze JC, Kuster A,et al. Prophylactic ibuprofen versusplacebo in very premature infants: a randomised, double - blind,placebo - controlled trial[ J]. Lancet,2004 ;364 : 1939 - 1944.
  • 7Dani C , Bertini G, Pezzati M, et al. Prophylactic ibuprofen for theprevention of intraventricular hemorrhage among preterm infants: amulticenter, randomized study [ J]. Pediatrics,2005 ; 115 : 1529 -1535.
  • 8林祝新,陈涵强,郑直,等.早期口服布洛芬治疗极低出生体重儿动脉导管未闭的临床研究[J].中国当代儿科学杂志,2012;14:502 -505.
  • 9Sosenko IR, Fajardo MF, Claure N,et al. Timing of patent ductusarteriosus treatment and respiratory outcome in premature infants : adouble - blind randomized controlled trial [ J ]. J Pediatr, 2012 ;160;929 -935.
  • 10Gokmen T, Erdeve 0, Altug N, et al. Efficacy and safety of oralversus intravenous ibuprofen in very low birth weight preterm infantswith patent ductus arteriosus[ J]. J Pediatr,2011 ;158:549 - 554.

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国际心血管病杂志
2012年 第3期

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