甲硝唑在人体胆汁中的动力学

Pharmacokinetic Studies on metronidazole in human bile

本文用反相高效液相色谱(HPLC)法对胆道疾病患者的胆汁中甲硝唑的浓度变化进行了研究。发现单剂量0.5g/100ml甲硝唑静脉滴注给药时,胆汁中甲硝唑的最高浓度为6.6±2.7μg/ml,只相当于最高血药浓度的55%。

Metronidazol pharmacokinetics in bile of patientswith biliary tract diseases were studied clinically byhigh-performance liquid chromatography. The resultsshowed that the maximum concentration of metroni-dazol in bile was 6.55±2.68g/ml after iv infusion ofsingle dose of 0.5/100ml. The maximum concentra-tion of metronidazol in bile was equivalent to 50%of the maximum serum concentration of metronidazol.The results provided a reliable evidence for correctuse of metronidazol in patients with biliary tractdiseases.