慢性丙型肝炎合并代谢综合征相关因素分析

Factors correlating metabolic syndrome with chronic hepatitis C

目的探讨慢性丙型肝炎(chronic hepatitis C,CHC)患者合并代谢综合征(metabolic syndrome,MS)的影响因素。方法选取本院2008年6月～2011年6月住院的未接受抗病毒治疗的CHC患者51例,根据患者是否合并MS分为MS组(23例)和非MS组(28例),比较两组的年龄、性别及体重指数(BMI)等差异,分析肝功能相关指标(TBil、DBil、ALT、AST、GGT、ALP),糖、脂代谢指标(FPG、CHO、TG、HDL、LDL、apoA、apoB)及HCV-RNA病毒载量。结果 MS组和非MS组患者年龄、BMI和性别构成差异无统计学意义(P均>0.05);两组患者TBil、DBil、ALT、AST、GGT、ALP、CHO、apoA、apoB、HCV-RNA病毒载量差异无统计学意义(P均>0.05);两组患者FPG、TG、HDL、LDL水平差异均有统计学意义(P均<0.05)。男、女性患者MS发生率分别为47.83%和42.86%,差异无统计学意义(P>0.05)。结论 CHC患者合并MS与糖、脂代谢因素密切相关(尤其与糖代谢相关性更为明显),与病毒本身无明确相关性。

Objective To investigate the viral and host factors for metabolic syndrome in chronic hepatitis C.Methods Subjects were 51 patients with chronic hepatitis C at Yijishan Hospital who had not received antiviral therapy from 2008 to 2011.Patients were divided into two groups,one with MS（23 patients） and another without MS（28 patients）.The groups were compared in terms of age,gender,BMI,Tbil,Dbil,ALT,AST,GGT,ALP;FPG,CHO,TG,HDL,LDL,apoA,apoB,and HCV-RNA viral load.Results There were no statistically significant differences（P 〉0.05） in the mean age,BMI,and gender of the group with MS and the group without MS.There were no significant differences in the levels of Tbil,Dbil,ALT,AST,GGT,ALP,CHO,apoA,and apoB and HCV-RNA viral load of the two groups.There were significant differences（P〈0.05）between the two groups in the levels of FPG,TG,HDL,and LDL.There was no significant difference in the incidence of MS in males（47.83%） and females（42.86%）.Conclusion Metabolic syndrome in chronic hepatitis C patients is closely correlated with glycometabolism and lipid metabolism（the correlation with glycometabolism is closer） and not with HCV itself