血清胃蛋白酶原和胃泌素检测对幽门螺杆菌相关十二指肠溃疡的意义

Significance of serum pepsinogen and gastrin detection in duodenal ulcers associated with Helicobacter pylori

目的测定十二指肠溃疡(DU)患者血清胃蛋白酶原PGⅠ、PGⅡ、PGⅠ/PGⅡ、血清胃泌素-17(G-17),分析胃肠肽类激素与幽门螺杆菌(Hp)引起的DU的相关性。方法选取胃镜检查确诊的患者306例,分成Hp阳性、Hp阴性DU组,Hp阳性、Hp阴性浅表性胃炎组,Hp阳性、Hp阴性萎缩性胃炎组,以ELISA检测血清PG和G-17含量。结果 Hp阳性DU组血清PGⅠ较慢性萎缩性胃炎和慢性浅表性胃炎Hp阳性组显著升高,差异有统计学意义(P均<0.05);Hp阴性DU组血清PGⅠ较萎缩性胃炎和慢性浅表性胃炎Hp阴性组明显升高,差异有统计学意义(P均<0.05)。DU各组PGⅠ/PGⅡ比值与慢性浅表性胃炎各组比较,差异有统计学意义(P均<0.05)。结论 Hp阳性DU患者血清PGⅠ和G-17升高;血清PGⅠ和G-17含量对分析胃肠肽类激素与Hp引起的DU以及症状程度和疗效评价有较好的参考价值。

Objective To determine levels of serum pepsinogen PG Ⅰ,PG Ⅱ,PG I / PG Ⅱ,and serum gastrin-17（G-17） in patients with a duodenal ulcer（DU） and analyze gastrointestinal peptide hormones and Helicobacter pylori（Hp）-induced DU.Methods Three hundred and six patients were diagnosed using gastroscopy and divided into an Hp-positive group with a DU and an Hp-negative group with a DU,an Hp-positive group and an Hp-negative group with superficial gastritis,and an Hp-positive and Hp-negative group with atrophic gastritis.ELISA was used to detect serum levels of PG and G-17.Results The Hp-positive group with a DU had a markedly higher serum PG Ⅰ level than did the Hp-positive groups with chronic atrophic gastritis and chronic superficial gastritis;the difference was statistically significant（P〈0.05）.The Hp-negative group with a DU had a markedly higher serum PG Ⅰ level than did the Hp-negative groups with atrophic gastritis and chronic superficial gastritis;the difference was statistically significant（P〈0.05）.Compared to both groups with chronic superficial gastritis,both groups with a DU had a greater PG I / PG II ratio;the difference was statistically significant（P〈0.05）.Conclusion Hp-positive patients with a DU have higher serum levels of PG Ⅰ and G-17.Along with analysis of gastrointestinal peptide hormones,PG Ⅰ and G-17 content in serum are good reference values for assessment of the extent of symptoms of a DU and its treatment.