摘要
循环miRNA是指存在血液等体液中的细胞外游离的miRNA,是由18~26个核苷酸组成的内源性非编码RNA分子。在细胞外稳定存在,对于放置时间较长、温度变化、pH值的高低、多次冻融具有良好的耐受性。在感染性疾病中,对于疾病的诊断、监测和预后判断具有重要作用。本文简述了循环miRNA及其与感染性疾病中的关系。
Circulating miRNAs refer to free miRNAs outside ceils present in blood and other bodily fluids. These miR- NAs are endogenous noncoding RNA molecules consisting of 18 to 26 nueleotides. They are stable outside ceils and can be left for long periods; these miRNAs are also highly resistant to temperature changes, pH changes, and multiple freeze- thaw cycles. Circulating miRNAs play an important role in the diagnosis, monitoring, and prognosis of infectious diseases. This review briefly describes the relationship between circulating miRNAs and infectious diseases.
出处
《中国病原生物学杂志》
CSCD
北大核心
2012年第4期309-310,315,共3页
Journal of Pathogen Biology
基金
北京市留学人员科技活动择优资助课题
北京市属高等学校人才强教计划资助项目(No.PHR201007112)
艾滋病研究北京市重点实验室项目(No.BZ0089)