消化道恶性肿瘤的细胞遗传学研究

Cytogenetic Study on Malignant Tumor of Alimentary Canal

采用细胞培养、制片、G显带、核型分析等细胞遗传学方法 ,对消化道恶性肿瘤患者外周血淋巴细胞及肿瘤细胞的染色体进行了研究 ,发现患者淋巴细胞染色体多无异常 ,而肿瘤细胞的染色体均有不同程度的改变 ,经常出现的结构改变 :胃癌7q- 、食管癌 del( 1 p)、结肠癌 del( 1 7p) ,这些改变可能分别是胃癌。

The method of cytogenetics as cell culture,plate mak ing,G banding and karyotype analysis et al has been adopted in the cytogenetic s tudy of patient′s chromosome of pripheral blood lymphocyte and maligmant tumor cell of alimentary canal.It is found that the lymphocyte chromosome of patient was mostly normal and that the tumor cells chromosome of patient are changed in varying degree.The structural abnormalities which occur most frequently in g astric cancer are 7q -,and in esophagic cancer are del(1p),and in colic cancer are del(17p).The 7q -,del(1p) and del(17p) might be regarded as the characteris tic chromosome rearrangement in gastric,esophagic and colic cancer.