呋喃苯胺酸对健康志愿者血清及唾液茶碱浓度的影响

Effect of furesemide on serum and saliva theophylline concentration in healthy subjects

本实验通过测定7名健康志愿者服用呋喃苯胺酸前后血清及唾液茶碱浓度,得到与国外文献相同的呋喃苯胺酸致茶碱浓度升高或降低的单方面结果,并发现两种结果并存(升高组n=4,降低组n=3);比较升降组的基础条件,均无显著差异(P>0.05);加服呋喃苯胺酸后,升高组血清茶碱浓度增高25.70%,唾液茶碱浓度增高6.74%;降低组血清茶碱浓度降低25.07%,唾液茶碱浓度降低16.56%,组间浓度有非常显著的差异(P<0.01);本文提出根据血清茶碱浓度,辅以毒副反应症状综合判断组别的初步设想。

Seven heallthy volunteers′serum and saliva con- centrations of theophylline were determined before and after administration of lasix (furosemide). The results were the same as reported in the literature that lasix makes the concentration of theophylline increase or decrease. We found that the two results coexist (the increased group n=4, the decreased group n=3). The comparison of basic condition in the two groups was not significant (p>0.05). After use of lasix the serum concentration of theophylline in the increased group enhanced by 25.7%, the saliva con- centration by 6.74%, whereas the serum concentration of theophylline in the decreased group reduced by 25.07%, the saliva concentration by 16.56%. Warked difference of concentration exsists between the two groups (p<0.01).It is suggested that to judge whether a group is up or down the serum concentration of theophylline should be dependent on with the signs of toxic and side reaction.