头孢曲松钠联合奥曲肽、奥美拉唑治疗肝硬化上消化道出血的疗效

Effect of Combined Treatment with Ceftriaxone, Octreotide and Omeprazole on Upper Gastrointestinal Hemorrhage in Patients with Cirrhosis

目的探讨头孢曲松钠联合奥曲肽、奥美拉唑治疗肝硬化上消化道出血的临床效果。方法将60例肝硬化上消化道出血患者按随机数字表法分为观察组和对照组,每组30例。2组均采用常规治疗,同时给予奥曲肽采用奥美拉唑联合治疗。在此基础上,观察组加用头孢曲松钠治疗。对2组患者的疗效、NO含量、住院时间、再出血及病死率进行比较。结果治疗后观察组血NO含量、住院时间、再出血率均明显低于对照组(均P<0.05)。观察组总有效率为93.33%,对照组总有效率为53.33%,2组比较差异有统计学意义(P<0.05)。2组治疗过程中均未见明显不良反应。结论头孢曲松钠联合奥曲肽、奥美拉唑治疗肝硬化上消化道出血的临床效果肯定,且安全。

Objective To investigate the effect of combined treatment with ceftriaxone, oct- reotide and omeprazole on upper gastrointestinal hemorrhage with cirrhosis. Methods Sixty pa- tients with upper gastrointestinal hemorrhage with cirrhosis were randomly divided into control group and observation group, with 30 patients in each group. All patients were given conventional treatment and combined octreotide and omeprazole treatment. Observation group was additionally treated with ceftriaxone. The curative effect, NO content, hospital stay, rebleeding rate and case fatality rate were compared between the two groups. Results Compared with control group, NO content in venous blood, hospital stay and rebleeding rate significantly decreased in observation group after treatment （P〈0.05）. In addition,the total effective rate in observation group was ob- viously higher than that in control group （93.33% vs 53.33% ,P〈0.05）. Conclusion Combined treatment with ceftriaxone,octreotide and omeprazole nal hemorrhage with cirrhosis. is effective and safe for upper gastrointesti-