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醛固酮对H9C2细胞的诱导作用 被引量：2

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摘要 目的探讨醛固酮对H9C2细胞凋亡的诱导作用。方法以培养的H9C2细胞为模型,观察100nmol/L醛固酮刺激H9C2细胞后3、6、12、24、48 h后盐皮质激素受体(MR)的表达情况、丙二醛(MDA)的含量以及超氧化物歧化酶(SOD)和Caspase-3、-8、-9的活性变化。结果醛固酮刺激H9C2细胞3 h开始,MR表达增高,6 h达高峰。TBARS法检测结果显示,醛固酮刺激后MDA含量在3 h开始增高,24 h达高峰。而SOD活性在醛固酮刺激后逐渐下降,24 h达最低。Caspase-3、-8、-9的活性在在醛固酮刺激后逐渐升高,24 h达高峰。与无醛固酮刺激的对照组比较差异有统计学意义(P<0.05)。结论醛固酮刺激H9C2细胞后,通过与MR结合诱导氧化应激导致细胞凋亡。
作者 卢晓梅 马玲 于艳秋
机构地区 中国医科大学基础医学院病理生理教研室
出处 《广东医学》 CAS CSCD 北大核心 2012年第10期1388-1389,共2页 Guangdong Medical Journal
关键词 醛固酮 H9C2细胞 凋亡
分类号 R363 [医药卫生—病理学]
  • 相关文献

参考文献10

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共引文献6

同被引文献15

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引证文献2

二级引证文献7

广东医学
2012年 第10期

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