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GSK-3β参与心肌缺血中细胞程序性死亡的研究进展 被引量：5

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摘要 细胞程序性死亡分为3种类型：1型为凋亡,2型为自噬,3型为坏死。线粒体在细胞程序性死亡中具有重要作用,它不仅是细胞的能量中心,而且是细胞存活和死亡的决定性因素。内源性和外源性的因素（如缺血再灌注、细胞毒细胞因子类和癌症化疗）可以损伤线粒体功能和以线粒体为平台的信号通路。缺血导致线粒体生产ATP的能力下降,进而导致细胞活力下降、细胞毒性代谢产物聚集。经过缺血期的处理,线粒体通透性转变孔（mPTP）在再灌注期间开放,
作者 车建鹏 晏浩 徐建军
机构地区 南昌大学第二附属医院胸心外科
出处 《广东医学》 CAS CSCD 北大核心 2012年第10期1498-1501,共4页 Guangdong Medical Journal
基金 国家自然科学基金资助项目(编号:30960381)
关键词 细胞程序性死亡 心肌缺血 GSK-3Β 线粒体通透性转变孔 线粒体功能 毒性代谢产物 缺血再灌注 细胞因子类
分类号 R329.28 [医药卫生—人体解剖和组织胚胎学]
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参考文献10

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同被引文献76

  • 1张荣军,游潮,蔡博文,杨咏波,苑玉清,贺民,李浩.Feeney法建立大鼠闭合性脑损伤模型及评估[J].中国修复重建外科杂志,2005,19(12):1015-1018. 被引量：37
  • 2沈诚,范士志,陈建明,李志平,何勇.抑制JAK/STAT通路对缺血再灌注损伤心肌TNF-α和IL-6表达的影响[J].重庆医学,2006,35(1):38-39. 被引量：14
  • 3刘海波,乔颖欣,刘冰,周家驹.中药化学数据库的数据仓库改造[J].中国药学杂志,2006,41(9):645-648. 被引量：14
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  • 5YUE Qing-xi,CAO Zhi-wei,GUAN Shu-hong,et al.Proteomics characterization of the cytotoxicity mechanism of ganodefic acid D and computer-automated estimation of the possible drug target network.Molecular Cellular Proteomics,2008,7(5):949-961.
  • 6Wen Zhi-ning,Wang Zhi-jun,Wang Steven,et al.Discovery of molecular mechanisms of traditional Chinese medicinal formula Si- Wu-Tang using gene expression microarray and connectivity map. PLoS One,2011,6(3):e18278.
  • 7Li Shao.Network systems underlying traditional Chinese medicine syndrome and herb formula.Current Bioinformatics,2009,4(3):188.
  • 8Gu Jiang-yong,Zhang Hu,Chen Li-rong,et al.Drug-target network and polyphamnacology studies of a traditional Chinese medicine for type II diabetes mellitus.Comput Biol Chem,2011,35(5):293-297.
  • 9Yan Jing,Wang Yun,Luo Si-jun,et al.TCM grammar systems:an approach to aid the interpretation of the molecular interactions in Chinese herbal medicine.J Ethnophannacol,2011,137(1):77-84.
  • 10Wang Yun.Entity grammar systems:a grammatical tool for studying the hierarchal structures of biological systems.Bulletin of Mathematical Biology,2004,66(3):4d7-471.

引证文献5

二级引证文献45

广东医学
2012年 第10期

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