硫酸亚铁与脂质过氧化作用

Ferrous sulfate and its Effect on lipid peroxidation

本文研究了硫酸亚铁在升高大鼠血色素同时,对体内脂质过氧化作用的影响。小剂量硫酸亚铁,给药时间较短时,不会引起丙二醛(MDA)升高,但谷胱甘肽过氧化物酶(GSH-P_X)的消耗增加。所给量的维生素C(VC)可减少自由基清除剂GSH-P_X的消耗。较大剂量硫酸亚铁,给药时间较长,可引起体内脂质过氧化作用加强。所给量VC无明显抗脂质过氧化作用。

The effects of ferrous sulfate on the lipidperoxidation in raising hemoglobin mice werestudied. Small doses of ferrous sulfate did notincrease malondialdehyde in a short time, but itdid decrease the scavenger of the free radical, GSH-Px. Larger doses of ferrous sulfate increased lipidperoxidation in a long time. Vitamin C decreasedthe consumption of the scavenger of the freeradical-GSH-Px, but with a larger dose of ferroussulfate in a long time, Vitamin C did not produceanti-lipid peroxidation effect.