B细胞非霍奇金淋巴瘤组织中GST-π的表达及意义

The expression and its significance of GST-π in B cell Non-Hodgkin Lymphoma

目的检测B细胞非霍奇金淋巴瘤(NHL)组织中谷胱甘肽-硫转移酶(GST-)并探讨在B细胞NHL中表达的意义及与化疗效果的关系。方法应用免疫组化EnVision法检测52例B细胞NHL组织和10例坏死增生性淋巴结炎组织中GST-的表达情况,并观察GST-表达与首疗程化疗效果的关系。结果在NHL患者GST-初治组中表达与对照组相比较,无统计学差异(>0.05);复发组GST-与对照组相比有统计学差异(<0.05);初治组与复发组相比较有统计学差异(0.05);GST-表达与首疗程化疗效果比较,有统计学差异(<0.05)。结论 GST-的表达情况可以作为B细胞NHL对化疗敏感性判断指标,也可能参与了B细胞NHL耐药性的产生。

Objective To detect the expression ofglutathione-sulfolransferase π （GST-π） in B cell non-hodgkin lymphoma （NHL） and to investigate the relationship in GST-π expression and chemotherapy effect. Methods Lmmunohistochemisty EnVision was used to detect the GST-n expression in 52 samples orB cell NHL and 10 samples ofnecrotizing lymphadenitis, and the relationship between GST-π expression and the chemotherapy effect were observed in the first course of treatment. Results Compared with control group, there＇s no different in GST-n expression in initial treatment group （P〉0.05）, while different in relapse group （P〈0.05）; Compared the expression of GST-π in initial treatment group and relapse group, there was different （P〈0.05）; Therapeutic effect in first course of treatment was related with the expression of GST-π （P〈0.05）. Conclusion The expression of GST-π may be as a criterion to judge the NHL chemotherapy sensitivity, and may be affected the drug-resistance generation of B cell NHL.