肾小球内凝血、纤溶因子的沉积与病理改变的关系

THE RELATIONSHIP BETWEEN LOCALIZATION FACTORS OF COAGUIATION AND FIBRINOLYSIS IN GLOMERULI AND PATHOLOGIC CHANGES

用免疫荧光法对118例原发或继发肾小球肾炎、肾小球内凝血,纤溶因子α_2—纤溶酶抑制因子(α_2—PI),纤溶酶原(PLG),纤维联接蛋白(FN),纤维蛋白相关抗原(FRA)的分布及与肾小球内组织病理损伤的关系进行了研究。健康对照组除FN在系膜区有沉积外、α_2—PI、PLG、FRA均为阴性,但在疾病情况下,特别是在重度系膜增殖性肾炎,膜增殖性肾炎,狼疮性肾炎中,这些因子不仅在肾小球内沉积增加,而且与球囊粘连,新月体的形成等病理变化密切相关。

Detection of alpha 2-plasmin inhibitor (α_2 -PI ), plasminogen (PLG), fibro-nectin (FN) and fibrinogen related antigen (FRA) by immunofluorescence in118 patients with primary and secondary glomerulonephritis were deseribed inthispaper.The study sbowed that in normal glomeruli, FN deposited in mesan-gial area and that α_2-PI and/or PLG, FN, FRA more pbserved in adhesionBowman's capsule and crescent in patients with severe mesangial proliferativeGN, membranoproliferative GN and lupus nephritis. It is postulated that the deposition of coagulation and fibrinolysis factorsin vivo might lead to the accumulation of glomezular fibrinogen deposition insevere glome ulonophritis. It is suggested that the deposits of α_2-PI and/or PLGFN, FRA in glomeruli might be one of the exacerbative factors in severe glo-merulonephritis.