Smad4蛋白在结直肠癌组织中的表达及其临床意义

Expression of Smad4 in Colorectal Cancer

目的:探讨Smad4蛋白在结直肠癌组织中的表达及其与患者临床表现和病理结果之间的关系。方法:采用免疫组织化学S-P法检测60例结直肠癌组织和27例相应的癌旁正常组织中Smad4的表达,并对表达情况评分。癌组织与癌旁正常组织中Smad4表达情况的比较,采用Mann-Whitney检验。结果:Smad4蛋白在结直肠癌组织和癌旁正常组织中的表达水平有显著差异(P<0.001)。Smad4的表达水平与肿瘤的浸润层次、淋巴结转移及Dukes分期显著相关(P<0.05)。结论:Smad4的低表达可能与结直肠癌的发生、发展有关,故Smad4有望作为结直肠癌的预后指标和基因靶向治疗的有效靶点。

Objective：To investigate the expression levels of Smad4 in colorectal cancer.Methods： The expression levels of Smad4 in cancer tissues from 60 patients with colorectal carcinoma and 27 corresponding adjacent normal tissues were detected by immunohistochemistry S-P method.Results： Compared with normal tissues,the immunohistochemical biopsy scores of Smad4 in primary tumor tissues of colorectal cancer were significantly lower（P〈0.001）.Smad4 expression was associated with tumor invasion,lymph node metastasis and Dukes staging（P〈0.05）.Conclusions： Decreased expression of Smad4 may be associated with the progression of colorectal cancer.