抗溃疡中药与胃肠粘膜血流Ⅱ——山莨菪碱对出血性休克大鼠胃肠粘膜表层微循环血液灌注的影响

EFFECT OF ANISODAMINE ON BLOOD VOLUME AND OXYGEN SUFFICIENCY OF GASTROINTESTINAL MUCOSAL SUFERFICIAL MICROCIRCULATION IN HEMORRHAGIC SHOCK RAT

用反射光谱法探讨山莨菪碱对出血性休克大鼠胃肠不同部位粘膜表层微循环血液量△Er和Hb氧饱和度(F)的影响。结果表明:1.正常麻醉大鼠胃肠不同部位粘膜△Er不同;F值未见部位差异。2.出血性休克大鼠胃肠不同部位粘膜△Er和F的降低程度不均等,以腺胃粘膜的降低为最明显,回肠次之。3.山莨菪碱10mg/kg,iv。对出血性休克大鼠胃肠各部粘膜的血液灌注均有不同程度的改善,以增加脾胃粘膜F值为最显著,回肠次之。4.山莨菪碱对出血性应激性粘膜损伤有保护作用。

The effect of anisodamine (AD) on blood volume (△Er) and oxygen sufficiency (F) of gastrointestinal mucosal superficial microcirculation in hemorrhagic shock rat was determined by the method of reflectance spectropho- tometry. The results demonstrated trat △Er of different parts of gastrointestinal mucosa in normal rat was different, while F of different parts showed no remarkable change. In hemorrhagic shock rat, the △Er and F of different parts of gastrointestinal mucosa decreased unevenly. Among them, the decrease of corpus was the greatest, ileum was the second. AD (10mg/kg B W. iv) made varied improvement on the mucosal blood supply of different parts of gastro- intestinal tract in hemorrhagic stress mucosal injury.