蛇毒、尿激酶对大白兔Masuji肾炎抗凝纤溶治疗的研究

THE EFFECTS OF ANTICOAGULANT AND DEFIBRINATION WITH ANCROD AND UROKINASE IN NEPHROTOXIC NEPHRITIS IN RABBITS

对大白兔的Masuji肾炎分别用蛇毒及尿激酶治疗。实验证明,蛇毒及尿激酶均有防止并溶解在肾小球内沉积的纤维素,消除新月体,防止肾小球硬化的作用。实验过程中发现随着新月体的消除,纤维蛋白(原)相关抗原(FRA)沉积减少,尿蛋白随之下降,尿素氮及肌酐也恢复到正常水平。但是沉积在肾小球内的IgG,实验组与对照组之间差别无统计学意义。

The debate of the value of anticoagulants in the treatment of renal disease has been going on for 15 to 20 years. In this paper, the re-examination of using ancrod and urokinase in nephrotoxic nephritis in rabbits was performed. In experimental glomerulonephritis both ancrod and urokinase have shown the prevention of deposition of fibrin in glomeruli with a resultant reduction in cellularity, prevention of crescent formation and glomerular sclerosis.Proteinuria continued was due to immunologic injury. Serum cretinine level, correlated well with glomerular fibrin deposition and crescent formation was significantly lower in treated animals. Ancrod and urokinase are more safety. However, deposition of anti-rabbit IgG along the glomerular basement membane (GBM) appeared to be the same in treated and untreated animals. It suggested that ancrod and urckinasc did not interfere in primary allergic events and that protection was related directly to defibrination.