联合用药对41例侵袭性真菌感染患者疗效的影响因素

Influencing factors of combination medication on curative efficacy of patients with invasive fungal infection

目的分析联合用药在治疗血液病患者合并侵袭性真菌感染(IFI)中的作用。方法回顾性分析2007年1月至2010年1月该院血液科采用联合用药方法治疗IFI的血液病患者41例的临床资料。结果恶性血液病患者的治疗有效率(57.1%)低于良性血液病患者(74.1%),P<0.05。接受化疗患者的治疗有效率(53.3%),低于接受免疫抑制剂治疗的患者治疗率(76.9%)。结论联合抗真菌治疗在血液病患者中治疗侵袭性真菌感染是可行、有效的,且耐药性好。

Objective To investigate the effects of combination antifungals on treating invasive fungal infection（IFI） in the patients with hematological diseases. Methods The clinical data in 41 patients with IFI treated by combination antifungals in our department from January 2007 to January 2010 were performed the retrospectively analysis. Results The effective rate was 57.1% in the malignant hematonosis patients,which was lower than 74.1% in the benign hematonosis patients（P〈0.05）. The effective rate was 53.3% in the chemotherapeutic patients and 76.9% in the patients receing immunosuppressive agents treatment. Conclusion Combination antifungal therapy is feasible and effective with good drug tolerance.