肝硬化腹水患者血浆心钠素浓度变化的探讨

A STUDY ON THE CHANGES OF PLASMA ANP CONCENTRATION IN PATIENTS WITH ASCITES DUE TO CIRRHCSIS

本文以放射免疫分析法测定72例肝硬化患者血浆心钠素浓度。结果为肝硬化患者血浆心钠素浓度高于正常对照组,腹水组高于无腹水组。其血浆心钠素浓度随腹水量的不同而有显著差异,即腹水量越多,心钠素浓度越高,随着腹水的消退,心钠素浓度逐渐下降。

In this paper the changes of plasma ANP concentration in potients withhepatocirrhosis were investigated by using radioimmunoassay.The results showedthat the concentration of plasma ANP in patients with hepatocirrhosis washigher than the control, and the concentration in potients with ascites due tocirrhosis was also higher than that in patients without ascites. The plasma ANP concentration changed significantly as the amount of ascites changed, i. e. themore increase of the amount of the ascites, the higher the plasma ANP concen-tration will be. Furthermore, the concentration became lower as the ascitesdecreased. In addition, a positive correlation existed between the plasma ANPconcentration and the renin activity in 33 petients with ascites due to cirrhosis,but there was no correlation between the plasma ANP and aldosterone.