支气管-肺泡灌洗液中CEA、SIgA和β_2-M测定对肺癌诊断的意义

DETERMINATION OF CEA, SIgA, β_2-M IN BRONCHOALVEOIAR LAVAGE FLUIDS AND ITS SIGNIFICANCE IN THE DIAGNOSIS OF LUNG CANCER

对20例肺癌和15例非癌性肺疾患患者的支气管-肺泡灌洗液(BALF)中CEA、SIgA和β_2-M含量行放免测定,同时测定血清CEA。结果:肺癌组BALF中CEA、SIgA含量显著高于非肺癌组。说明测定BALF中CEA较测定血清CEA对肺癌与非肺癌的鉴别诊断更有意义。当联合CEA/BALF>15μg/ml、CEA/血清>15μg /ml和SIgA/BALF>112μg/ml中至少两项时,对肺癌诊断的敏感性达45%,特异性达100%;3项指标均阴性时的阴性预示值为60.23%。

Bronchoalveolar lavage fluids (BALF) were reeovered from 20 patients withlung cancer and 15 patients with benign lung diseases. CEA, SIgA and β_2-Min BALFs and CEA in serum were determined by RIA. The results showed thelevels of CEA and SIgA in BALFs in patients with lung cancer were sig-nificantly higher than those in patients with benign pulmonary diseases(P<0.05;P<0.01); no significant difference was found between levels of β_2-M inBALFs in the patients with lung cancer and benign pulmonary diseases(P>0. 05).The results showed that determination of CEA in BALFs is more powerful inthe discrimination between lung cancer and benign pulmonary diseases than thatin serum. In this study the combination of at least two positive tests of CEA/BALF>15ng/ml, CEA/serum>15ng/ml and SIgA/ml>112μg/ml was the mostsignificant in the diagnosis of lung cancer with sensitivity of 45.00%, specificityof 100%. The combination of three negative tests showed a negative predicativevalue of 60.23%.