促红细胞生成素对极低出生体质量儿贫血限制性输血治疗的影响

THE EFFECT OF ERYTHROPOIETIN ON ANAEMIA IN VERY LOW BIRTH WEIGHT INFANT TREATED WITH RESTRICTIVE BLOOD TRANSFUSION

目的探讨促红细胞生成素(erythropoietin,EPO)对极低出生体质量儿贫血限制性输血治疗的影响。方法选取早产极低出生体质量儿50例,对照组(20例)在生后第8天给予力蜚能胶囊和维生素E,治疗组(30例)在此基础上使用重组人类基因-EP0。按照限制性输血适应证进行输血。观察2组输血率、输血次数、每次输血量、住院时间和并发症等。结果治疗组血红蛋白、红细胞压积和网织红细胞计数在治疗后l、3、7周均明显高于对照组(P<0.05);治疗组输血率、输血次数和每次输血量均明显低于对照组(P<0.01,P<0.05);治疗组并发症发生率、新生儿重症监护病房住院时间和总住院时间均明显低于对照组(P<0.05)。结论 EP0能明显减少极低出生体质量儿贫血限制性输血的输血人数、输血次数和每次输血量,减少并发症和住院时间,并具有很好的远期疗效,值得临床推广应用。

Objective To investigate the effect of erythropoietin （EPO） on anaemia in very low birth weight infant treated with restrictive blood transfusion. Methods Fifty cases of very low birth weight premature infant were selected and divided into 2 groups. The control group （20 cases） were given Niferex capsule and vitamin E at the postnatal day 8. The treatment group （30 cases） were given rhu - Epo on the basis of those of control group. The restrictive blood transfusion was performed in both groups according to the indication of restrictive blood transfusion. Blood transfusion rate, transfusion frequency, each transfusion blood volume, hospital stay and complications of both groups were observed. Results The hemoglobin （Hb）, hematocrit（Hot） and reticulocyte（Ret） in the treatment group were significantly higher than that of control group （ both P 〈 0.05 ） 1,3,7 weeks after treatment ; The blood transfusion rate ,transfusion frequency and each transfusion volume in treatment group was significantly lower than that of control group （P 〈0.01 ,P 〈0.05） ; The incidence of complications,neonatal intensive care unit （NICU） length of stay and total hospital stay of the treatment group were significantly lower than those of the control group （P 〈 0.05）. Conclusion EPO can significantly reduce the number of anemia in very low birth weight infant treated with restrictive blood transfusion, transfusion frequency and blood volume of each transfusion, reduce complications and hospital stay, with a good long - term effect. It is worthy of clinical application.