苔藓宁对口腔扁平苔藓患者的免疫调节作用

IMMUNOREGULATORY EFFECTS OF TAIXIANNING DECOCTION IN PATIENTS WITH ORAL LICHEN PLANUS

目的观察苔藓宁对口腔扁平苔藓(oral lichen planus,OLP)患者免疫功能的影响及调节作用。方法 51例OLP患者连续服用中药方剂苔藓宁3个月,对比西药治疗方法,观察其疗效以及对OLP患者体液免疫和细胞免疫的调节作用。结果苔藓宁治疗组总有效率88.2%,西药治疗组为72.5%,2组疗效差异有统计学意义(P<0.05)。苔藓宁治疗组患者治疗后,体液免疫和细胞免疫趋于正常,与治疗前比较差异有统计学意义(P<0.05),西药治疗组治疗前后各项免疫指标的变化差异无统计学意义(P>0.05)。结论苔藓宁对OLP患者的免疫功能具有调节作用,能有效改善患者的临床症状,疗效显著。

Objective To explore the effect and immunoregulation of taixianning decoction on oral lichen planus（OLP） patients. Methods Fifty - one OLP patients were required to take taixianning decoction for 3 months. Then, the therapeutic effect and change of humoral immunity and cellular immunity were compared with those of patients who took western medicine. Results The total effective rate of taixianning decoction group and western medicine group were 88.2% and 72.5% , respectively. Compared with western medicine group, taixianning decoction group had higher therapeutic effect （P 〈 0. 05 ）. The index of humoral immunity and cellular immunity was notably changed （ P 〈 0.05 ） after the treatment with taixianning decoction, closing to the normal value. After the treatment with western medicine,there was no notable change. Conclusion Taixianning decoction have better curative effect to improve immunological function of oral lichen planus patients.